![]() Motor cortex excitability was studied by single and paired TMS before and at 1 h and 6 h after the oral administration. Subjects were required to take either 900 mg of VE (valerenic acid 0.8%) or placebo (an equal dose of vitamin E). Methods: Fifteen healthy volunteers participated in a double-blind, randomized, cross-over, placebo-controlled study. ![]() In this study, we investigated the effects of a single dose of VE on cortical excitability as assessed with transcranial magnetic stimulation (TMS). ![]() Noninvasive brain stimulation protocols can be used to elucidate the mechanisms of action of psychoactive substances at the cortical level in humans. Although the anxiolytic and sedative effects are mainly attributed to the modulation of GABA-ergic transmission, the mechanism of action has not been fully investigated in humans. Background: Valeriana officinalis extract (VE) is a popular herbal medicine used for the treatment of anxiety and sleep disorders.
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